Fri Mar 21 2025

29 articles - From Friday Mar 14 2025 to Friday Mar 21 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Liver Transpl

International liver transplantation society practice guideline update on portopulmonary hypertension.

In this document, approved for publication by the ILTS executive council, we provide an update to the prior guidelines with expert recommendations to guide and advance POPH management. Recommendations in these guidelines are based on expert opinion and available evidence and were agreed upon by consensus.

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Pancreatology

Recommendations from the European guidelines for the diagnosis and therapy of pancreatic exocrine insufficiency.

The European guidelines for the diagnosis and therapy of PEI provide evidence-based recommendations concerning key aspects of the etiology, diagnosis, therapy, and follow-up, based on current available evidence. These recommendations should serve as a reference standard for existing management of PEI and as a guide for future clinical research. This article summarizes the recommendations and statements.

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Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Association between more plant-based diets and 24-hour urinary creatinine excretion in 98,813 Dutch females and males: a cross-sectional study.

Individuals with identities favoring plant-based diets had a lower dietary protein intake and a lower CER, indicating lower total body muscle mass. When plant-based diets are being promoted, it is important to monitor and evaluate the potential public health impact on muscle mass.

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Energy intake is associated with dietary macronutrient densities: inversely with protein and monounsaturated fat and positively with polyunsaturated fat and carbohydrate among postmenopausal females.

Among U.S. postmenopausal females lower EI was associated with diets relatively high in protein or MUFA, and higher EI was associated with diets relatively high in PUFA or added sugars. These associations are of public health importance, but are mostly missed using self-reported dietary density assessments. Self-reported energy underestimation is substantially associated with self-reported macronutrient densities. This study is registered with clinicaltrials.gov identifier NCT00000611.

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Individualized nutritional intervention versus routine care for gestational diabetes prevention: A randomized controlled trial.

Among females at risk of GDM, an individualized nutritional intervention based on Chinese dietary guidelines provided before the OGTT did not prevent GDM but helped to manage GWG appropriately and improved pregnancy outcomes.

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Regular-fat and low-fat dairy foods and cardiovascular diseases: Perspectives for future dietary recommendations.

Strategies focusing primarily on reduction of energy-dense, nutrient-poor foods, the main source of SFAs in Western diets, rather than on the fat content of dairy foods, are more likely to benefit the population's cardiovascular health. Future research is needed to understand better the place of regular-fat and low-fat dairy foods within healthy eating patterns.

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Inflamm Bowel Dis

Stromal Cell Subsets Show Model-Dependent Changes in Experimental Colitis and Affect Epithelial Tissue Repair and Immune Cell Activation.

The relative abundance changes of stromal cell subsets during experimental colitis differ between 3 established colitis models. Treatment with IBD therapies influences stromal subset abundance, indicating their importance in IBD pathogenesis, possibly through affecting epithelial migration, and T-cell activation.

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J Crohns Colitis

Development and validation of a risk prediction tool for the diagnosis of inflammatory bowel disease in patients presenting in primary care with abdominal symptoms.

In the validation cohort the model tended to slightly overestimate IBD risk at higher risk thresholds. A risk model using patient demographics, symptoms, and laboratory results accurately predicted IBD, UC, and CD at 1, 2, 3, and 5 years after symptom onset, potentially aiding in prioritizing patients for referral or faecal calprotectin (FC) testing in primary care.

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Serum extracellular RNAs as a non-invasive approach to differentiate IBD subtypes: a proof-of-concept study.

Liquid biopsies may represent a novel, non-invasive approach in IBD biomarker development. Although larger in-depth studies are needed, this proof-of-concept study bridges non-invasive measurements with established IBD mechanisms, offering a promising tool for accurately distinguishing CD from UC.

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T cell branched glycosylation as a mediator of colitis-associated colorectal cancer progression: a potential new risk biomarker in Inflammatory Bowel Disease.

From the clinical standpoint, we demonstrated that branched N-glycosylation levels detected in inflamed lesions from IBD patients predicted CAC progression with a sensitivity of 83.3% and specificity of 67.9%, when assessed together with age at diagnosis. Overall, we here disclosed a new mechanism underlying CAC development, identifying a potential clinical biomarker plausible to improve the efficacy of cancer surveillance programs through the early identification of high risk IBD patients, for preventive clinical and therapeutic strategies.

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Liver Transpl

A snapshot of challenges and opportunities faced by the scientific workforce in liver transplantation - a survey of the International Liver Transplantation Society (ILTS).

Looking ahead, advancing technologies, machine learning/artificial intelligence, multi-omics, xenotransplantation, and machine perfusion were highlighted as areas with potential to significantly shift the paradigm in the near future. Our survey captured insights from B&TR scientists within the ILTS, identifying both challenges and opportunities for future developments and aiding in the strategic direction of the society's initiatives.

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Combining radiomics and imaging biomarkers with clinical variables for the prediction of HCC recurrence after liver transplantation.

In al integrated models, the high-risk groups had a shorter RFS than the corresponding low-risk group. CT-based radiomics and imaging parameters beyond the Milan criteria representing aggressive behavior, along with history of bridging therapies, show potential for predicting HCC recurrence after LT.

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Treatment algorithm for the management of concomitant splenic artery aneurysms in adult Liver Transplant recipients.

During the mean follow-up of 53 months, no case of SAA sac expansion and SAA-related or treatment-related mortality was observed. Despite a high incidence of post-treatment splenic infarction, our treatment algorithm was safe and effective as an adjunctive treatment to prevent SAA-related mortality in adult LT recipients.

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Pancreas

Correlation between Fatty Pancreas and Coronary Artery Calcium Score in a Dyslipidemic Population.

Therefore, ultrasound could be employed to classify fatty pancreas, which could serve as an alternative predictor of coronary artery calcification incidence. It is a non-invasive, radiation-free, convenient, and cost-effective method that could be used for risk assessment of coronary atherosclerosis, to identify people at a risk of coronary heart disease at an early stage, and to intervene promptly to control the disease development.

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Development and Validation of the Comprehensive Acute Pancreatitis Pain Core Outcome Set (CAPPOS): Study Protocol.

CAPPOS will provide a validated, multidimensional core outcome set to optimize pain assessment in AP. It will also facilitate standardized reporting in clinical trials, advancing research and care for AP-related pain.

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Impact of Abdominal Aortic Calcification on Pancreas Graft Survival in Patients Undergoing Simultaneous pancreas-kidney Transplantation.

AAC is associated with death-uncensored pancreas graft survival in patients undergoing SPK. Evaluation of AAC could be useful for predicting post-PTx prognosis.

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Pancreatology

Concealed pancreatic cancer in acute pancreatitis: Early MRCP and EUS surveillance improves prognosis and identifies high-risk patients.

These findings support prioritizing early surveillance for AP patients with subthreshold MPD dilation and moderately severe disease. Further large-scale studies are warranted to validate these strategies in clinical practice.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Clin Nutr

Kangaroo care and the mother-infant dyad: skin-to-skin contact increases human milk transfer in vulnerable infants.

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Inflamm Bowel Dis

Improving Brain-Gut Studies in Crohn's Disease: Methodological Considerations.

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Total Proctocolectomy Versus Subtotal/Total Colectomy for Neoplasia in Patients With Inflammatory Bowel Disease and Primary Sclerosing Cholangitis.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Inflamm Bowel Dis

Risk Factors for Contraceptive Failure and Unintended Pregnancy Among Women With Inflammatory Bowel Disease.

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Utilization of Super-Resolution Contrast-Enhanced Ultrasonography in Diagnosing Intestinal Behçet's Disease With Enterovesical Fistula.

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Liver Transpl

Achieving transplant equity: A feasible solution for uninsured patients.

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Building a better mouse trap in liver retransplantation risk prediction: Is resoft the end or the beginning?

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From screening to action: Social determinants and early outcomes in pediatric Liver Transplant recipients.

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Portal vein interposition in pediatric living donor Liver Transplantation: Which vein graft type is best?

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Pancreas

Replacing Liposomal Irinotecan with Standard Irinotecan in Pancreatic Adenocarcinoma: Should We Follow Suit and Substitute Without Dispute?

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Total Pancreatectomy with Islet Autotransplant: Building a Multidisciplinary Program.

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Underuse of Pancreatic Enzyme Replacement Therapy Among Patients with Gastroenteropancreatic Neuroendocrine Neoplasms and Exocrine Pancreatic Insufficiency.

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Letters&Replies

Letters to the editors and authors’ replies